Makoto Honda

The paper uses polygenic risk scores and Mendelian randomization to show circadian genetic factors contribute to idiopathic hypersomnia.

The paper investigates hypomethylation patterns in immune-mediated diseases, finding that solo-WCGW hypomethylation correlates with immune cell proliferation and disease-specific immune dynamics.

The paper identifies global hypomethylation in T cells of narcolepsy type 1 patients, linked to solo-WCGW motifs and T cell proliferation.

The paper identifies region-specific gene isoforms in the human brain using long-read transcriptome sequencing and links them to DNA methylation patterns.

The paper shows that narcolepsy with cataplexy is caused by epigenetic silencing of hypocretin neurons, not their destruction, using QRFP as a marker and methylation analysis.

This study identifies a genetic association between Kleine-Levin Syndrome and variants in the TRANK1 gene, with increased risk linked to birth difficulties.

This study identifies genetic risk loci for narcolepsy, showing enrichment in immune cells and suggesting autoimmune modulation via T cell receptor chains and influenza-A infection.