Author

Huifeng Zhao

Zhejiang UniversityORCID 0000-0003-4243-9671Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:contrastive learning· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:benchmark study· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Dejun JiangiD· 2 shared Odin ZhangiD· 2 shared Tingjun HouiD· 2 shared Yufei HuangiD· 2 shared Chang‐Yu HsiehiD· 1 shared Chenqing HuaiD· 1 shared Dong Ming GuoiD· 1 shared Haitao LiniD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersBioinformatics

Dejun JiangORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ECloudGen: Leveraging Electron Clouds as a Latent Variable to Scale Up Structure-based Molecular Design

Odin Zhang, Jieyu Jin, Zhenxing Wu, Jintu Zhang, Po Yuan, Yuntao Yu, Haitao Lin, Haiyang Zhong, Xujun Zhang, Chenqing Hua, Weibo Zhao, Zhengshuo Zhang, Kejun Ying, Yufei Huang, Huifeng Zhao, , Tingjun Hou

ECloudGen improves molecular design by using electron clouds as latent variables, generating more potent binders and exploring broader chemical space than existing methods.

Nature Computational Science · Oct 15, 2025Peer-reviewedBioinformatics

PepPCBench is a Comprehensive Benchmark for Protein-Peptide Complex Structure Prediction with AlphaFold3

Silong Zhai, Huifeng Zhao, Jike Wang, Shaolong Lin, Tiantao Liu, Dejun Jiang, Huanxiang Liu, Yu Kang, Xiaojun Yao, Tingjun Hou

The paper introduces PepPCBench, a benchmark framework to evaluate AlphaFold3's performance in predicting protein-peptide complexes using a curated dataset.

bioRxiv · Apr 8, 2025 · PreprintBioinformatics

PPFlow: Target-aware Peptide Design with Torsional Flow Matching

Haitao Lin, Odin Zhang, Huifeng Zhao, Dejun Jiang, Lirong Wu, Zicheng Liu, Yufei Huang, Stan Ziqing Li

PPFlow designs target-aware peptides using torsional flow matching, achieving state-of-the-art performance in peptide drug generation and optimization.

bioRxiv · Mar 7, 2024 · PreprintMolecular Biology