David Sexton

This study identifies six genes associated with hand grip strength using rare protein-coding variants in 340,319 individuals and shows additive effects with common variants.

The paper performs single-variant and gene-based association analyses of 4,529 phenotypes using exome data from 426,370 UK Biobank individuals, finding associations linked to variant frequency and deleteriousness.

This study examines the impact of rare protein-truncating variants on human lifespan using whole-exome sequencing data from the UK Biobank, identifying significant associations with several genes.

OmicsView provides an interactive platform for analyzing omics data, enabling researchers to explore disease pathology and identify biomarkers using preprocessed datasets.

CellDepot provides a web platform for uploading, querying, and comparing scRNA-seq datasets with visualization tools to support data sharing and analysis.

The paper describes exome sequencing of 200,643 UK Biobank participants, providing a rich resource of coding variants for genetic and drug discovery research.

The paper identifies genetic and RNAi-based pairwise interactions between lipid-related genes that modulate plasma and cellular lipid levels, suggesting potential drug target pairs for lipid-lowering therapies.

Cellxgene VIP enhances single cell data analysis by providing interactive visualization, advanced analytical tools, and multi-modal data integration for scRNA-seq, spatial transcriptomics, and multiome datasets.