Zheng Ser

The paper introduces ProteomeGenerator2, a tool that integrates genomic and transcriptomic data to generate proteomes including non-canonical variants, and benchmarks it using synthetic and biological data.

The paper presents an integrative structural analysis of the Smc5/6 complex in budding yeast, revealing unique structural features and functional interactions among its subunits.

This paper optimizes cross-linking mass spectrometry (XL-MS) for in situ protein interaction mapping using DSSO cross-linkers, CSM score calibration, and protease combinations, improving interaction density and coverage.