Xiaolan Zhao

Replication fork remodeling proteins, Smc5/6 and Rtt107, promote palindrome-mediated genome instability

The paper identifies a pathway involving Smc5/6 and Rtt107 that promotes palindrome-mediated genome instability through cruciform formation and cleavage.

A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis

This study reveals a non-catalytic role for RFC in stabilizing PCNA-Polδ interactions during DNA synthesis, essential for processive replication.

A transposase-derived gene required for human brain development

This study identifies PGBD5 as a transposase-derived gene essential for brain development in humans and mice, with deficiency causing intellectual disability and seizures.

Telomeric SUMO level influences the choices of APB formation pathways and ALT efficiency

This study shows that high telomeric SUMO levels promote APB nucleation and enhance ALT efficiency through BLM recruitment and DNA synthesis.

Srs2 binding to PCNA and its sumoylation contribute to RPA antagonism during the DNA damage response

This study investigates how Srs2 helicase interacts with PCNA and undergoes sumoylation to antagonize RPA and regulate the DNA damage checkpoint in yeast.

The SMC5/6 complex is required for maintenance of genome integrity upon APOBEC3A-mediated replication stress

This study identifies the SMC5/6 complex as essential for genome stability in cells with active APOBEC3A, showing that its loss leads to increased DNA damage and replication stress.

Integrative analysis reveals unique features of the Smc5/6 complex

The paper presents an integrative structural analysis of the Smc5/6 complex in budding yeast, revealing unique structural features and functional interactions among its subunits.