Molecular BiologybioRxivPreprint
In silico and functional characterisation of an ultra-rare CFTR mutation identifies novel lasso motif interactions regulating channel gating
Sharon L. Wong, Nikhil T Awatade, Miro A. Astore…·Shafagh A. Waters
The paper functionally and structurally characterizes an ultra-rare CFTR mutation, showing it responds to specific potentiators and correctors, with altered lasso motif interactions affecting channel gating.
DOI 10.1101/2021.12.12.472297