Author

Sharon L. Wong

UNSW SydneyORCID 0000-0001-8447-9239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Approach:simulation· 1

Frequent Co-Authors

Adam JafféiD· 3 shared Katelin M. AllaniD· 3 shared Shafagh A. WatersiD· 3 shared Alexander CapraroiD· 2 shared Iveta ŠlapetováiD· 2 shared Michael J. CarnelliD· 2 shared Miro A. AstoreiD· 2 shared Po‐Chia CheniD· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersMolecular Biology

Adam JafféORCID

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3 papers

Recent·Most cited

Gene-Corrected Basal Cells Restore CFTR In Vitro; Transplants Regenerate Epithelium in a Preclinical Sinus Model

Katelin M. Allan, Shaoyan Zhang, Sharon L. Wong, Alexander Capraro, Alexandra McCarron, Daniel F. Skinner, Egi Kardia, Ye Zheng, Ling Zhong, Chai‐Ann Ng, Jessica Lilian Bell, Nigel Farrow, Bala Umashankar, Catherine G. Banks, Cristan A. Herbert, , Shafagh A. Waters

bioRxiv · Jul 21, 2025 · PreprintCell Biology

Molecular dynamics and theratyping in airway and gut organoids reveal R352Q-CFTR conductance defect

Sharon L. Wong, Nikhil T. Awatade, Miro A. Astore, Katelin M. Allan, Michael J. Carnell, Iveta Šlapetová, Po‐Chia Chen, Jeffry Setiadi, Elvis Pandzic, Laura K. Fawcett, John R. Widger, Renee M. Whan, Renate Griffith, Chee Y. Ooi, Serdar Kuyucak, , Shafagh A. Waters

The paper characterizes the functional and structural defects of the R352Q CFTR mutation using patient-derived organoids and molecular dynamics simulations, showing residual function restored by potentiators but not correctors.

American Journal of Respiratory Cell and Molecular Biology · Apr 26, 2022Peer-reviewedMolecular Biology

In silico and functional characterisation of an ultra-rare CFTR mutation identifies novel lasso motif interactions regulating channel gating

Sharon L. Wong, Nikhil T Awatade, Miro A. Astore, Katelin M. Allan, Michael J. Carnell, Iveta Šlapetová, Po‐Chia Chen, Alexander Capraro, Laura Katherine Fawcett, Renee Megan Whan, Renate Griffith, Chee Yee Ooi, Serdar Kuyucak B, Adam Jaffé, Shafagh A. Waters

The paper functionally and structurally characterizes an ultra-rare CFTR mutation, showing it responds to specific potentiators and correctors, with altered lasso motif interactions affecting channel gating.

bioRxiv · Dec 12, 2021 · PreprintMolecular Biology