Jukka Laine

This paper demonstrates that the Nicking Loop targeted library preparation method works well with the DNBSEQ sequencing platform, matching performance of linear libraries on Illumina.

The paper introduces Nicking Loop, a method for converting DNA into circular single-stranded DNA for NGS, showing improved reproducibility, sensitivity, and compatibility with sequencing platforms.

This study shows that Parp14 deficiency in mice worsens colitis by impairing epithelial barrier integrity and altering inflammation-related gene expression.