Lauri Polari

Lamin A/C regulates the compartment-specific contributions of immune and stromal cells to intestinal inflammation and colitis-associated colon cancer

This study identifies lamin A/C as a regulator of intestinal inflammation and tumorigenesis by modulating immune and stromal cell functions in mouse models and human IBD biopsies.

Keratin 7 protein presence in stool is indicative of active pediatric-onset inflammatory bowel disease

This study identifies keratin 7 (K7) protein in stool as a noninvasive biomarker for active pediatric-onset inflammatory bowel disease, showing high sensitivity and specificity.

The expression of colonic keratins is elevated in IBD, reduced in microscopic colitis, and unchanged in IBS : a retrospective study

This study examines colonic keratin expression in IBD, MC, and IBS, finding elevated levels in IBD, reduced in MC, and unchanged in IBS.

Exacerbated salmonellosis in poly(ADP-ribose) polymerase 14 deficient mice

This study shows that Parp14 deficiency in mice worsens S. Typhimurium infection by disrupting tissue architecture and mucosal inflammation in the large intestine.

Genetically induced mouse model for colon-specific epithelial cell tumorigenesis driven by loss of K8 and Apc

This study develops a genetic, colon-specific mouse model of colorectal cancer driven by K8 and Apc loss, showing increased tumorigenesis and reduced K8 expression in human patients.