Gunes Ekin Atilla‐Gokcumen

This study identifies ER-localized ceramide accumulation as a driver of replicative senescence through impaired ceramide trafficking.

This study identifies acid sphingomyelinase (ASMase) as a key regulator of ceramide levels during necroptosis, showing that its inhibition reduces membrane permeability by impairing MLKL pore formation.

This study shows that ET-resistant breast cancer cells are more sensitive to ceramide-induced endoplasmic reticulum stress, mediated through TRAM1, leading to cell death.

This study shows that mitochondrial calcium signaling regulates branched-chain amino acid catabolism and the urea cycle in fibrolamellar carcinoma through transcriptional control of metabolic genes.