Author

Miguel A. Varela

University of OxfordORCID 0000-0003-4376-9381Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Assay:long-read sequencing· 1 Organism:rat· 1

Frequent Co-Authors

Ruben D. ArteroiD· 2 shared A LópeziD· 1 shared Adolfo López de MunainiD· 1 shared Aline Huguet-LachoniD· 1 shared Ana Díaz-Maqueda· 1 shared Anchel González‐BarrigaiD· 1 shared Andrea García-Rey· 1 shared Anna Colom-RodrigoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenetics

Ruben D. ArteroORCID

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2 papers

Recent·Most cited

GeneticsThe American Journal of Human GeneticsPeer-reviewedFeb 20, 2026

Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for Myotonic Dystrophy type 1

Irene González-Martínez, Estefanía Cerro-Herreros, Marc Carrascosa-Sàez…·Ruben D. Artero

This study develops chemically optimized miR-23b antimiRs that enhance muscle uptake and restore MBNL1 function in DM1 models, showing improved efficacy and safety.

4 citationstop 2%

humanmouse

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Molecular BiologybioRxivPreprintJun 20, 2025

Dysregulated MEG3 in Myotonic Dystrophy 1: nuclear retention, pathological role, and therapeutic correction by antisense conjugates.

David Seoane-Miraz, Jessica Stoodley, Natalia Galindo Riera…·Miguel A. Varela

This study shows MEG3 is upregulated in DM1 and exhibits nuclear retention, with antisense conjugates correcting MEG3 levels in mice.

DOI 10.1101/2025.06.20.658327

mousehuman

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