Aneel K. Aggarwal

This paper describes the structure and function of M.BceJIV, a DNA methyltransferase in Burkholderia cenocepacia, showing it binds two DNA sequences simultaneously for methylation.

This study resolves crystal and cryo-EM structures of the SPARTA system to elucidate its activation mechanism involving nucleic acid binding and oligomerization.

The paper shows that phosphorylated CTCF binds the SIRT1 promoter under oxidative stress, activating a cardioprotective transcriptional program in cardiomyocytes.