Author

Rudi Micheletti

Howard Hughes Medical InstituteORCID 0000-0002-4895-6007Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Michael G. RosenfeldiD· 2 shared Agnieszka D’Antonio‐ChronowskaiD· 1 shared Alice E. Zemljic‐HarpfiD· 1 shared Amir Gamliel· 1 shared Ana Catarina SilvaiD· 1 shared Aneel K. AggarwaliD· 1 shared Angelo PeloneroiD· 1 shared Arun PadmanabhaniD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Michael G. RosenfeldORCID

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2 papers

Recent·Most cited

Recruitment of CTCF to the SIRT1 promoter after Oxidative Stress mediates Cardioprotective Transcription

Tobias Wagner, Priyanka Priyanka, Rudi Micheletti, Meyer J. Friedman, Sreejith J. Nair, Amir Gamliel, Havilah Taylor, Xiaoyuan Song, Miook Cho, Soohwan Oh, Wenbo Li, Jeehae Han, Kenneth A. Ohgi, Madeline Abrass, Agnieszka D’Antonio‐Chronowska, , Yousin Suh

The paper shows that phosphorylated CTCF binds the SIRT1 promoter under oxidative stress, activating a cardioprotective transcriptional program in cardiomyocytes.

bioRxiv · May 17, 2024 · PreprintCell Biology

A Transcriptional Switch Governing Fibroblast Plasticity Underlies Reversibility of Chronic Heart Disease

Michael Alexanian, Pawel F. Przytycki, Rudi Micheletti, Arun Padmanabhan, Lin Ye, Joshua G. Travers, Bárbara González‐Terán, Ana Catarina Silva, Qiming Duan, Sanjeev S. Ranade, Franco Felix, Ricardo Linares-Saldana, Li Li, Clara Youngna Lee, Nandhini Sadagopan, , Deepak Srivastava

The paper identifies a reversible transcriptional switch in cardiac fibroblasts that governs fibroblast plasticity and contributes to chronic heart disease, with MEOX1 as a key regulator.

Nature · Jun 23, 2021Peer-reviewedMolecular Biology