Yousin Suh

A longevity-associated ubiquitin E3 ligase UBE3C governs lamin B1 homeostasis through selective autophagy and delay senescence

This study identifies UBE3C as a longevity-associated E3 ligase that maintains nuclear lamina integrity by modulating LMNB1 and LBR through selective autophagy, delaying senescence.

Identification of functional non-coding variants affecting Alzheimer's disease risk by Massively Parallel Reporter Assay

The paper identifies functional non-coding variants affecting Alzheimer's disease risk using MPRA and validates their effects through CRISPR/Cas9.

Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families

The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.

Epigenetic CRISPR Screening of 9p21.3 Non-Coding Regions identifies Cis-Regulatory Elements of P16INK4a and P15INK4b Controlling Cellular Senescence

The paper identifies cis-regulatory elements controlling cellular senescence by performing CRISPR screens in human mesenchymal stromal cells, revealing a primate-specific SINE element that modulates P16INK4a and P15INK4b.

Two retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity

This study shows that PNMA1 and PNMA4, derived from retrotransposons, are essential for reproductive capacity, as their absence leads to subfertility and hormonal changes in mice and associations with reproductive traits in humans.

Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex

The paper identifies senescent cell signatures in the human dorsolateral prefrontal cortex using spatial transcriptomics and single nucleus RNA sequencing, revealing heterogeneity and cell-type-specific aging patterns.

Transcriptomic signatures of mouse ovarian aging and estropausal transition at single cell resolution

This study uses single-cell transcriptomics to analyze mouse ovarian aging and identifies molecular changes associated with the estropausal transition.

An eQTL-based Approach Reveals Candidate Regulators of LINE-1 RNA Levels in Lymphoblastoid Cells

The paper identifies candidate regulators of LINE-1 RNA levels in lymphoblastoid cells using eQTL analysis and validates some candidates experimentally.

Recruitment of CTCF to the SIRT1 promoter after Oxidative Stress mediates Cardioprotective Transcription

The paper shows that phosphorylated CTCF binds the SIRT1 promoter under oxidative stress, activating a cardioprotective transcriptional program in cardiomyocytes.

In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood

This study identifies PEDF as a systemic factor in young blood that rejuvenates cells and tissues, using an in vitro heterochronic parabiosis system.

A systems biology-based identification and in vivo functional screening of Alzheimer's disease risk genes reveals modulators of memory function

The paper identifies LOAD risk genes through systems biology and shows their impact on memory function via neuronal endosomal dysfunction in C. elegans.

Ultrafine mapping of chromosome conformation at hundred basepair resolution reveals regulatory genome architecture

This paper introduces two 3C-derived methods, Tri-4C and Tri-HiC, for ultrafine mapping of chromatin interactions at 100 basepair resolution, revealing regulatory genome architecture and enhancer-promoter loops.

Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of p16INK4a

The paper identifies a functional variant in the 9p21.3 locus associated with glaucoma risk and shows it increases p16INK4a expression by disrupting YY1 binding.

The regulation of Insulin/IGF-1 signaling by miR-142-3p associated with human longevity

This study identifies miR-142-3p as a regulator of human longevity by modulating the insulin/IGF-1 signaling pathway in B-cells and mice.

Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammation

The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.

Decoding the Variant-to-Function Relationship for LIPA, a Risk Locus for CAD

The paper links LIPA risk alleles to increased monocyte/macrophage LIPA expression, which exacerbates atherosclerosis through enhanced PU.1 binding and altered macrophage function.

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.

The regulatory landscapes of human ovarian ageing

This study uses single-nuclei multi-omics analysis to identify molecular and cellular changes in human ovarian ageing and links genetic variants to age at natural menopause.

A joint analysis of longevity and age-related disease variants for gene expression association

This study analyzes genetic variants associated with longevity and age-related diseases to understand their impact on gene expression.

Transcriptome analysis reveals the difference between \"healthy\" and \"common\" aging and their connection with age-related diseases

The paper compares gene regulations in 'healthy' and 'common' aging using GTEx data to identify differences and connections with age-related diseases.

A novel approach of human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases

This paper introduces ANDRU, a human data-driven approach to discover geroprotectors by targeting aging and age-related disease subnetworks, identifying potential targets and compounds in adipose and artery tissues.