Peter Ruoff

The paper uses computational modeling to show that a regulated intranucleoid dNTP pool explains mtDNA number conservation and 7S DNA synthesis rate changes during the cell cycle in human cells.

The paper models blood sodium regulation in blue crabs using a negative feedback mechanism of Na,K-ATPase to explain salinity adaptation and osmoregulation patterns.

This paper analyzes how two antagonistic negative feedback loops regulate compensatory responses to environmental changes, identifying three control modes and their implications for homeostasis and rheostasis.

The paper revisits background compensation in frequency-controlled homeostats with coherent feedback, showing that frequency resetting and phase response curves are background compensated.

The paper describes how coherent feedback can eliminate background influences in homeostatic systems, showing that oscillatory and non-oscillatory controllers can maintain consistent responses regardless of background levels.

The paper analyzes eight integral controller motifs in vertebrate photoadaptation, finding two classes of controllers with distinct responses to background changes and their relation to psychophysical laws.

The paper develops a computational model of calcium homeostasis in non-excitable cells, showing sustained oscillations in calcium levels due to hysteretic properties and cooperativity in calcium transport mechanisms.

The paper analyzes enzyme-catalyzed dual-E controllers and identifies two operational modes based on kinetic mechanisms and conditions for their function.

The paper introduces an amplified derepression controller using multisite inhibition and positive feedback to maintain robustness against time-dependent perturbations without breaking down due to low inhibitor concentrations.

The paper examines how p53 regulation shifts between oscillatory and non-oscillatory states in response to DNA damage, highlighting the roles of Per2, ATM, and Mdm2 in maintaining homeostasis.

The paper introduces a new antagonistic regulatory system with a unique setpoint and integral/double integral action, demonstrating its asymptotic stability through analytical methods.