Senescent cells cluster CTCF on nuclear speckles to sustain their splicing program
Spiros Palikyras, Vassiliki Varamogianni‐Mamatsi, Yajie Zhu, Athanasia Mizi, Shyam Ramasamy, Jonas Viken Grini, Isabel Liebermann, Athanasia Stavropoulou, Andrés Penagos‐Puig, Tuba Sena Ogurlu-Tank, Konstantinos Kydonakis, Ioanna Papadionysiou, Deniz Bartsch, Yulia Kargapolova, Natalia Rosalía Morero, , Argyris Papantonis
This paper identifies senescence-induced CTCF clusters (SICCs) and shows they sustain the senescence splicing program by repurposing nuclear speckle components.
Nature Aging · Jul 21, 2026Peer-reviewedCell Biology