Author
Asgeir Kobro‐Flatmoen
Norwegian University of Science and TechnologyORCID 0000-0002-2379-2982Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2021-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 14 mutual co-author links10 papers
Recent·Most cited
- Molecular BiologybioRxivPreprint
A DNA mass conservation mechanism underpins cellular mtDNA number regulation
Jagir R. Hussan, Asgeir Kobro‐Flatmoen, Peter Ruoff, Stig William Omholt
The paper uses computational modeling to show that a regulated intranucleoid dNTP pool explains mtDNA number conservation and 7S DNA synthesis rate changes during the cell cycle in human cells.
DOI 10.64898/2026.07.08.737183 - NeuroscienceAlzheimer s & DementiaPeer-reviewed
Aβ Antibodies Target Not Only Amyloid Plaques But Also Distinct Brain Cells And Vessels
Gehua Wen, Nils Lindblom, Xiaoni Zhan…·Gunnar K. Gouras
This study shows that Aβ antibodies target not only amyloid plaques but also neurons, glial cells, and blood vessels in AD mouse models.
2 citationstop 4% - NeurosciencebioRxivPreprint
High reelin expression can explain why the entorhinal cortex is a cradle for Alzheimer's disease
Asgeir Kobro‐Flatmoen, Jagir R. Hussan, Peter John Hunter, Stig William Omholt
The paper shows that high reelin expression in alECLII neurons promotes A{beta}42 accumulation, leading to early neuronal demise in Alzheimer's disease.
DOI 10.1101/2025.06.04.655278 - NeurosciencePLoS Computational BiologyPeer-reviewed
Intraneuronal binding of amyloid beta with reelin -implications for the onset of Alzheimer's disease
Asgeir Kobro‐Flatmoen, Stig William Omholt
The paper investigates the interaction between reelin and intracellular amyloid-beta in ECLII neurons, proposing that high reelin expression may protect against AD but also predispose these neurons to AD due to higher Aβ production capacity.
- NeuroscienceBrain Structure and FunctionPeer-reviewed
Bnip3 expression is strongly associated with reelin-positive entorhinal cortex layer II neurons
Stig William Omholt, Raissa Lejneva, Mariá José Lagartos-Donate…·Asgeir Kobro‐Flatmoen
The paper confirms that Bnip3 expression correlates with reelin levels in entorhinal cortex layer II neurons, indicating higher metabolic demand near the rhinal fissure.
6 citations - NeurosciencebioRxivPreprint
Reverse Engineering of Feedforward Cortical-Hippocampal Microcircuits for Modelling Neural Network Function and Dysfunction
Katrine Sjaastad Hanssen, Nicolai Winter‐Hjelm, Salome Nora Niethammer…·Ioanna Sandvig
This study reverse engineers feedforward cortical-hippocampal neural networks using microfluidic devices to model brain network dynamics and pathology impact.
- NeurosciencebioRxivPreprint
A combined DTI-fMRI approach for optimizing the delineation of posteromedial vs. anterolateral entorhinal cortex
Ingrid Framås Syversen, Daniel Reznik, Menno P. Witter…·Christian F. Doeller
This study combines DTI and fMRI in healthy adults to delineate human homologues of medial and lateral entorhinal cortex subdivisions, revealing a confined border between posteromedial and anterolateral regions.
- NeurosciencebioRxivPreprint
Microdissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice
Katrine Sjaastad Hanssen, Menno P. Witter, Axel Sandvig…·Asgeir Kobro‐Flatmoen
The paper describes a method to microdissect and culture adult entorhinal layer II neurons from AD model mice, showing they remain viable and functionally active for over two months.
DOI 10.1101/2022.12.05.519179 - NeuroscienceNeuroImagePeer-reviewed
Structural connectivity-based segmentation of the human entorhinal cortex
Ingrid Framås Syversen, Menno P. Witter, Asgeir Kobro‐Flatmoen…·Christian F. Doeller
This study segments the human entorhinal cortex using structural connectivity, identifying MEC and LEC homologues based on differential connections to specific brain regions.