Thamali Ayagama

This study investigates the role of lysosomal Ca2+ signaling in heart rhythm and atrial function, finding that NAADP pathway inhibition affects SAN pacemaker activity and cAMP production in atrial myocytes.

This study identifies cardiac involvement in Niemann-Pick type C through ECG abnormalities, fibrosis, and transcriptomic changes in patients and Npc1-/- mice.

The paper identifies proteomic signatures of mitochondrial dysfunction in goats with atrial fibrillation, highlighting oxidative phosphorylation subunits and HSPA9 as a regulatory hub.

This study shows that IP3R activation in atrial myocytes increases cAMP, which can be inhibited by IP3R blockers, but ventricular myocytes show cAMP increases independent of IP3R.

The paper uses proteomics and other methods to study endolysosomal changes in a goat model of atrial fibrillation, identifying upregulated pathways and specific proteins.

The paper presents a modified density gradient method for isolating endo-lysosomal proteins from cardiac tissue and reports proteomic analysis of these fractions in guinea pigs.