Antony Galione

This paper discovers a novel 5-HT2A receptor-linked signaling pathway involving NAADP-mediated lysosomal Ca2+ release, showing reduced hallucinogenic and neuroplastic effects upon genetic ablation of the pathway in mice.

This study investigates the role of lysosomal Ca2+ signaling in heart rhythm and atrial function, finding that NAADP pathway inhibition affects SAN pacemaker activity and cAMP production in atrial myocytes.

This paper introduces sdAb(mNG), a high-affinity nanobody that enables versatile applications for mNG-tagged proteins, including imaging, immunoprecipitation, and in vivo manipulation.

This paper demonstrates that levacetylleucine modulates TFEB activity in a bidirectional manner, normalizing lysosomal function in both wild-type and NPC1 knockout cells.

This paper shows that NALL activates TFEB, enhancing lysosomal and autophagic function, which may explain its therapeutic effects in neurodegenerative diseases.

This study shows that lysosomal calcium signaling via NAADP and calcium-stimulated adenylyl cyclase 1 and 8 contributes to the acute α-adrenergic response in atrial myocytes.

The paper uses proteomics and other methods to study endolysosomal changes in a goat model of atrial fibrillation, identifying upregulated pathways and specific proteins.

The paper presents a modified density gradient method for isolating endo-lysosomal proteins from cardiac tissue and reports proteomic analysis of these fractions in guinea pigs.