Jennie Close

This study uses single-nucleus RNA-seq, ATAC-seq, and Multiome to analyze Alzheimer's disease across multiple brain regions, revealing shared and region-specific cellular vulnerabilities.

The paper maps AD-related pathological changes in the caudate nucleus at cellular resolution, identifying distinct features and cell type-specific responses.

The paper defines major axes of human basal ganglia astrocyte specialization using a multimodal atlas and identifies enhancer code for targeted viral tools.

The paper creates a cross-species consensus atlas of primate basal ganglia cell types using multiomic data from human, macaque, and marmoset, identifying 61 conserved cell types and a novel hybrid medium spiny neuron type.

This paper creates a cross-species spatial transcriptomic atlas of the basal ganglia in human, rhesus macaque, and common marmoset, revealing conserved molecular organization and cell type-specific compartments.

The paper introduces MerQuaCo, an open-source tool to automatically detect and quantify imperfections in spatial transcriptomics data, improving quality assessment.

This paper creates a high-resolution transcriptomic and spatial cell type atlas of the whole adult mouse brain, revealing spatial organization and transcription factor codes for cell types.

The paper uses single nucleus RNA-sequencing to analyze human cortical areas, revealing cell type proportions and gene expression patterns that correlate with functional connectivity and areal specialization.

The paper identifies transcriptomic and morpho-electric diversity in human neocortical layer 1 interneurons, revealing greater subclass distinction compared to mouse.

This study uses single nucleus transcriptomics to compare human and non-human primate cortical tissues, identifying human-specific gene expression patterns and their potential functional roles.

The paper uses viral labeling and Patch-seq to define morpho-electric properties of GABAergic interneurons in human neocortex, revealing functional insights and reclassifying some SST neurons into PVALB subclass.

This study investigates the role of Sox6 in maintaining somatostatin interneuron subtype identity during migration, finding that its removal reduces subtype diversity in the mature cortex.

This study compares cellular organization and interactions in human and mouse cortex using single-cell transcriptome imaging, finding conserved laminar organization but divergent cell-cell interactions in humans.

The paper spatially maps human cortical cell types using in situ sequencing and single-nucleus RNA-sequencing to create a first spatial atlas of human cortical cells.

PaintSHOP provides an interactive platform for designing oligonucleotide FISH experiments, integrating machine learning to predict probe specificity and generate standardized probe sets.

The paper compares cell types in human and mouse cortex using single nucleus RNA-sequencing, finding conserved architecture with species-specific differences.

The paper presents a method combining spatial transcriptomics with optogenetic mapping to resolve cell type characteristics in mouse cortex.

The paper shows that h-channels contribute to differences in electrophysiological properties between human and mouse supragranular pyramidal neurons.

The paper identifies a novel human cortical GABAergic interneuron subtype with unique transcriptomic, morphological, and physiological features not observed in rodents.