Cancer BiologyNature CommunicationsPeer-reviewed
MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, enhances tumor-microglia crosstalk, and drives immune checkpoint blockade efficacy.
Kwang‐Soo Kim, Junyi Zhang, Victor Andrés Arrieta…·Adam M. Sonabend
This study identifies the MAPK/ERK pathway as a key regulator of glioma susceptibility to immune checkpoint blockade, showing it modulates interferon responses, T cell recruitment, and tumor-microglia interactions.