Dieter Henrik Heiland

Aquaporin-4 Regulates Edema, Sustains Astrocyte Differentiation, and Constrains Immunosuppressive Remodeling in Glioblastoma

This study shows that AQP4 regulates edema, maintains astrocyte differentiation, and limits immunosuppressive changes in glioblastoma.

A pro-inflammatory effector-memory T cell program links peripheral EBV priming to CNS autoimmunity

The paper identifies an EBV-specific T cell program in MS patients that contributes to CNS autoimmunity through B cell and myeloid cell activation.

Temozolomide-associated inflammatory-repair remodeling in recurrent glioblastoma exposes a ROCK-linked therapeutic vulnerability

This study shows that preoperative temozolomide exposure in recurrent glioblastoma leads to inflammatory-repair remodeling and a ROCK-linked therapeutic vulnerability, which can be targeted by fasudil.

MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, enhances tumor-microglia crosstalk, and drives immune checkpoint blockade efficacy.

This study identifies the MAPK/ERK pathway as a key regulator of glioma susceptibility to immune checkpoint blockade, showing it modulates interferon responses, T cell recruitment, and tumor-microglia interactions.

Local translation drives glioblastoma heterogeneity and tumor invasion

This study identifies local translation as a driver of glioblastoma tumor microtubes and invasion by linking subcellular protein synthesis to invasive cell states.

Microglial Fructose Metabolism Is Essential for Glioblastoma Growth

This study shows that microglial fructose metabolism via GLUT5 is critical for glioblastoma growth, as GLUT5-KO mice live longer with reduced tumor progression.

Voxel-accurate MRI-microscopy correlation enables AI-powered prediction of brain disease states

BRIDGE correlates MRI with cellular data to predict brain disease states using deep learning and high-resolution microscopy.

Neuronal precursor cell persistence in Ganglioglioma is associated with ECM remodeling and immune cell infiltration

This study uses spatial transcriptomics to identify transcriptional programs in gangliogliomas that link ECM remodeling, immune infiltration, and persistent neuronal precursor-like states to tumor biology.

Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology

This study shows serotonergic neurons promote high-grade glioma growth via 5HT2A receptor activation, with psychedelic drugs enhancing this effect.

Targeting CHEK2-YBX1&YBX3 regulatory hub to potentiate immune checkpoint blockade response in gliomas

This study identifies the CHK2-YBX1&YBX3 hub as an immunosuppressive mechanism in gliomas and shows that targeting it with SU056 enhances immune checkpoint blockade efficacy.

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing

This study uses retrograde tracing to characterize neuron-tumor networks in glioblastoma and shows that targeting these networks can enhance therapeutic outcomes.

Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability

The paper identifies an epigenetic neural signature in glioblastoma that correlates with poor prognosis and therapeutic vulnerability.

Inferring spatially transient gene expression pattern from spatial transcriptomic studies

SPATA bundles spatial transcriptomics analysis: spatially resolved expression, how transcriptional programs shift by region, and expression changes along spatial trajectories.