Pierre Barraud

This study identifies m1A58 as a conformational checkpoint that links tRNAiMet maturation to translation initiation and stress responses by stabilizing tRNA structure and processing.

This paper evaluates limitations of deep learning in biomolecular structure prediction, highlighting the benefits of explicit ion modeling for improving conformational accuracy.

This study shows that ADAR1 dimerization affects site-specific RNA editing, with dimer disruption altering editing efficiency at specific sites without abolishing overall activity.

This study reports cryo-EM structures of human mitochondrial tRNA maturation complexes, revealing the molecular mechanisms of tRNA processing steps and their sequential order.

This paper shows that the Legionella pneumophila effector LegK1 suppresses RNA silencing by interacting with Argonaute proteins and activating NF-κB signaling, enhancing bacterial virulence.

This study uses time-resolved NMR to track tRNA maturation in yeast, revealing a sequential and hierarchically controlled modification process.