Matthias Heiß

This study shows that the carbocyclic antimetabolite cAzadC increases TET2 expression and 5hmdC levels, leading to reactivation of anti-tumor responses in AML models.

This study assesses ALKBH1 activity in vitro and in human cell lines using mass spectrometry, finding no significant impact on tRNA modifications under optimal conditions.

The paper identifies NSUN6 as a methyltransferase that specifically targets mRNA 3UTR regions with the CTCCA motif, affecting translation termination but not essential for mouse development.

This study uses time-resolved NMR to track tRNA maturation in yeast, revealing a sequential and hierarchically controlled modification process.