Muralidhar L. Hegde

This study evaluates a multifunctional nanozyme therapy for intracerebral hemorrhage, showing it accelerates hematoma clearance and reduces genome damage and senescence.

This study shows that fructose-2,6-bisphosphate (F2,6BP) restores genome repair and motor function in TDP-43 pathology-driven motor neuron diseases.

This paper shows that F2,6BP restores mitochondrial genome integrity in Huntington's Disease by rescuing PNKP activity and mitochondrial function.

This study shows TDP43 regulates DNA mismatch repair genes, affecting genome stability in neurodegenerative and cancer contexts.

This study investigates PARG99 as a cytosol-specific intervention to reduce FUS-associated toxicity in ALS models while preserving DNA repair.