Author

Daniel Darnell

St. Jude Children's Research HospitalORCID 0000-0003-4489-5726Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Allister J. LoughraniD· 1 shared Amy SchneideriD· 1 shared Bekim SadikovićiD· 1 shared Beth ManniD· 1 shared Cassandra RastiniD· 1 shared Ching‐Heng ChouiD· 1 shared Christy W. LaFlammeiD· 1 shared Cliff S. GuyiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Allister J. LoughranORCID

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2 papers

Recent·Most cited

Genetic & Genomic MedicineNature CommunicationsPeer-reviewedAug 6, 2024

Diagnostic Utility of Genome-wide DNA Methylation Analysis in Genetically Unsolved Developmental and Epileptic Encephalopathies and Refinement of a CHD2 Episignature

Christy W. LaFlamme, Cassandra Rastin, Soham Sengupta…·Heather C. Mefford

This study evaluates genome-wide DNA methylation analysis in genetically unsolved DEEs, identifying 10 causative or candidate genetic causes and refining a CHD2 episignature.

31 citationstop 1%

humanDNA methylation

𝕏 PostBluesky

NeurosciencebioRxivPreprintOct 19, 2021

Fetal neural progenitors process TLR signals from bacterial components to enhance proliferation and rework brain development

Beth Mann, Jeremy Chase Crawford, Kavya Reddy…·ELAINE I. TUOMANEN

The paper shows bacterial PAMPs activate TLR2/6 on fetal NPCs, enhancing proliferation and altering brain development in mice.

DOI 10.1101/2021.10.19.464985

mousebulk RNA-seq

𝕏 PostBluesky