Author

Christine Lyn Le Maitre

University of SheffieldORCID 0000-0003-4489-7107Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 3 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Abbie L. A. BinchiD· 2 shared Andrew W. McCaskieiD· 1 shared Eleftheria ZegginiiD· 1 shared Exarchos KanelisiD· 1 shared Francis Kiptengwer ChemorioniD· 1 shared Graham R. S. RitchieiD· 1 shared Ingrid MeulenbeltiD· 1 shared Janet PiñeroiD· 1 shared

Activity by Year

2017-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

Abbie L. A. BinchORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintDec 11, 2025

Understanding the physiological behaviour of disc cells in an in vitro imitation of the healthy and degenerated disc niche

Joseph Snuggs, Shaghayegh Basatvat, Exarchos Kanelis…·Christine Lyn Le Maitre

This study develops media formulations to mimic the physiological conditions of healthy and degenerate intervertebral discs and assesses their effects on cell viability and secretome.

DOI 10.64898/2025.12.09.693181

humanproteomics

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Systems Biologynpj Systems Biology and ApplicationsPeer-reviewedJan 31, 2025

Nucleus Pulposus Cell Network Modelling in the Intervertebral Disc

Sofia Tseranidou, Maria Segarra-Queralt, Francis Kiptengwer Chemorion…·Jérôme Noailly

The paper develops a regulatory network model of nucleus pulposus cells to simulate ECM regulation in intervertebral discs, showing how perturbations affect catabolic and anabolic processes.

13 citationstop 2%

humanstatistical model

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Systems BiologyScientific ReportsPeer-reviewedAug 15, 2017

Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis

Julia Steinberg, Graham R. S. Ritchie, Theodoros I. Roumeliotis…·Eleftheria Zeggini

The paper identifies 49 genes and pathways associated with osteoarthritis progression using integrative epigenomics, transcriptomics, and proteomics in human chondrocytes from OA patients.

118 citationstop 1%

humanDNA methylation

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