Structural Basis of μ-Opioid Receptor-Targeting by a Nanobody Antagonist
Jun Yu, Amit Kumar, Xuefeng Zhang, Charlotte Martin, Kevin Van holsbeeck, Pierre Raia, Antoine Koehl, Toon Laeremans, Jan Steyaert, Aashish Manglik, Steven Ballet, Andreas Boland, Miriam Stoeber
This paper describes a nanobody antagonist of the μ-opioid receptor, revealing its structural basis and designing peptide analogues with antagonistic activity.
Nature Communications · Oct 9, 2024Peer-reviewedMolecular Biology