Toon Laeremans

This study determines the structures of native SV2A, revealing its binding modes for tetanus neurotoxin and anti-epileptic drugs, and provides insights into toxin-receptor interactions and drug specificity.

This paper describes a nanobody antagonist of the μ-opioid receptor, revealing its structural basis and designing peptide analogues with antagonistic activity.

This study identifies a topological switch in CFTR's NBD1 domain that regulates channel function and contributes to misfolding in F508del-CFTR.

This study develops a biosensor to map opioid receptor activation in neurons, showing drugs activate receptors in the Golgi and dendrites, while peptides activate them in the plasma membrane and endosomes.