Aaron M. Johnson

This study identifies an EZH2 variant associated with immunodeficiency and shows it impairs PRC2 function by disrupting H3K27me3 methylation at specific genomic regions.

The paper identifies a novel inter-subunit interaction in the SIR complex that facilitates the switch from histone deacetylation to chromatin compaction, essential for gene repression.

This study identifies an m6A modification in HOTAIR lncRNA that regulates its function in breast cancer by affecting chromatin localization and gene expression.

The paper identifies Hnrnpa2b1 as a key RBP regulating myogenic differentiation through post-transcriptional control in skeletal muscle regeneration.

The paper introduces an improved eCLIP method called m6A-eCLIP (meCLIP) that enables precise identification of m6A residues at single-nucleotide resolution with reliable confidence metrics.