Justin T. Roberts

The paper uses MOA-seq to map transcription factor occupancy in hypoxia-treated human endothelial cells, identifying thousands of hypoxia-responsive sites and clustering them into HIF1A-associated and independent TF groups.

The paper identifies thousands of alternative splicing events in human vascular endothelial cells under hypoxia, revealing a more complex and dynamic transcriptional response than conventional RNA-seq suggests.

This study shows that progranulin deficiency worsens age-related vascular damage in mice, affecting endothelial function and vascular remodeling.

The paper identifies LG4 enhancers that physically interact with gene promoters via G4:G4 DNA structures and links SNPs in these enhancers to CF lung disease severity.

This study identifies an m6A modification in HOTAIR lncRNA that regulates its function in breast cancer by affecting chromatin localization and gene expression.

SALTS is a web-based ncRNA transcriptomics suite that enables comprehensive analysis of sncRNA and lncRNA data without requiring computational expertise.

The paper introduces an improved eCLIP method called m6A-eCLIP (meCLIP) that enables precise identification of m6A residues at single-nucleotide resolution with reliable confidence metrics.