Bradley B. Olwin

This study shows that YAP and TAZ redundantly regulate muscle regeneration by controlling proliferation and migration of muscle stem cells, revealing genetic redundancy as essential for regenerative robustness.

This study identifies TDP-43 as essential for satellite cell maintenance and muscle repair by supporting stress response transcripts during quiescence-to-GAlert transition.

This study shows that aged fibroblasts impair muscle stem cell self-renewal by depositing excessive fibronectin in a 3D hydrogel co-culture system.

This study shows that TDP-43 is essential for building and maintaining sarcomeres, as its absence leads to muscle atrophy and disrupted sarcomere organization.

This study shows that the aged muscle tissue environment limits muscle stem cell function, and combined interventions can partially restore muscle mass in aged mice.

This study shows that activating FGFR1 restores Integrin-β1-mediated fibronectin sensing in aged satellite cells, improving their regenerative capacity.

The paper identifies Hnrnpa2b1 as a key RBP regulating myogenic differentiation through post-transcriptional control in skeletal muscle regeneration.

The paper investigates myonuclear maturation dynamics in aged and adult regenerating mouse skeletal muscle, finding that transcriptional heterogeneity arises during maturation and is altered in aged muscle.