Brian G. Rash

The paper assesses AAV serotype transduction efficiency in human cortical organoids, showing cell-specific tropism and donor variability.

This study creates a C4A overexpressing neuroimmune cortical organoid model that exhibits schizophrenia endophenotypes like inflammation and synaptic pruning.

This paper develops an automated system to scale patient-derived brain organoids, revealing consistent donor and batch effects and demonstrating reproducible disease phenotypes in tuberous sclerosis models.

The paper models the progression of human neural stem cells in vitro, showing they transition through organizer states before committing to cortical excitatory or inhibitory neuronal fates.