Kevan D. Shah

Cell specificity of adeno-associated virus (AAV) serotypes in human cortical organoids

The paper assesses AAV serotype transduction efficiency in human cortical organoids, showing cell-specific tropism and donor variability.

Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes

This study creates a C4A overexpressing neuroimmune cortical organoid model that exhibits schizophrenia endophenotypes like inflammation and synaptic pruning.

Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration

This paper introduces GEDI, a fluorescent biosensor that detects early irreversible commitment to cell death in neurons, enabling real-time and high-throughput analysis of neurodegeneration.

Demuxalot: scaled up genetic demultiplexing for single-cell sequencing

Demuxalot improves genetic demultiplexing for single-cell RNA sequencing by enhancing accuracy and efficiency in multi-batch, multi-donor studies.

Optimization and scaling of patient-derived brain organoids uncovers deep phenotypes of disease

This paper develops an automated system to scale patient-derived brain organoids, revealing consistent donor and batch effects and demonstrating reproducible disease phenotypes in tuberous sclerosis models.