Author

Gaia Skibinski

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Andy Lash· 3 shared Brian G. RashiD· 3 shared Carlos Castrillo· 3 shared Douglas Flanzer· 3 shared Jordan M. SorokiniD· 3 shared Justin Nicola· 3 shared Kevan D. ShahiD· 3 shared Luigi Enriquez· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Andy Lash

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cell specificity of adeno-associated virus (AAV) serotypes in human cortical organoids

Morgan M. Stanton, Harsh N. Hariani, Jordan M. Sorokin, Patrick M. Taylor, Sara Modan, Brian G. Rash, Sneha B. Rao, Luigi Enriquez, Daphne Quang, Pei-Ken Hsu, Justin H. Paek, Dorah Owango, Carlos Castrillo, Justin Nicola, Pavan Ramkumar, , Gaia Skibinski

The paper assesses AAV serotype transduction efficiency in human cortical organoids, showing cell-specific tropism and donor variability.

bioRxiv · Apr 13, 2023 · PreprintNeuroscience

Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes

Morgan M. Stanton, Sara Modan, Patrick M. Taylor, Harsh N. Hariani, Jordan M. Sorokin, Brian G. Rash, Sneha B. Rao, Alejandro Tobon, Luigi Enriquez, Brenda Dang, Dorah Owango, Shannon K. O’Neill, Carlos Castrillo, Justin Nicola, Kathy Ye, , Gaia Skibinski

This study creates a C4A overexpressing neuroimmune cortical organoid model that exhibits schizophrenia endophenotypes like inflammation and synaptic pruning.

bioRxiv · Jan 20, 2023 · PreprintNeuroscience

The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

Adrienne E.D. Stormo, Farbod Shavarebi, Molly FitzGibbon, Elizabeth M. Earley, Hannah D. Ahrendt, Lotus Lum, Erik Verschueren, Danielle L. Swaney, Gaia Skibinski, Abinaya Ravisankar, Jeffrey van Haren, Emily J. Davis, Jeffrey R. Johnson, John Von Dollen, Carson Balen, , Annie OF Hiniker

This study identifies TRIM1 as an E3 ligase that ubiquitinates LRRK2, regulating its localization, degradation, and toxicity in Parkinson's Disease.

The Journal of Cell Biology · Jan 5, 2022Peer-reviewedMolecular Biology

Optimization and scaling of patient-derived brain organoids uncovers deep phenotypes of disease

Kevan D. Shah, Rishi Bedi, Alex Rogozhnikov, Pavan Ramkumar, Zhixiang Tong, Brian G. Rash, Morgan M. Stanton, Jordan M. Sorokin, Cagsar Apaydin, Anthony Batarse, Julia Bergamaschi, Robert M. Blattner, Spencer Brown, Anthony Bosshardt, Carlos Castrillo, , G. Sean Escola

This paper develops an automated system to scale patient-derived brain organoids, revealing consistent donor and batch effects and demonstrating reproducible disease phenotypes in tuberous sclerosis models.

bioRxiv · Aug 26, 2020 · PreprintNeuroscience