Mechanisms of AAV neutralization by human alpha-defensins
Jessica M. Porter, Kaitlin R. Hulce, Mackenzi S. Oswald, Kevin Busuttil, Shanan N. Emmanuel, Antonette D. Bennett, Robert McKenna, Jason G. Smith
This study identifies how human alpha-defensins neutralize AAV2 and AAV6 by blocking viral entry and nuclear trafficking, revealing a common mechanism for inhibiting non-enveloped viruses.
PLoS Pathogens · Jul 18, 2025Peer-reviewedMicrobiology