Jason G. Smith

The paper identifies viral E3 ligase activity as a conserved trigger of NLRP1 inflammasome activation, expanding effector-triggered immunity against viral pathogens.

This study compares intracellular trafficking of defensin-resistant and canonical adenovirus entry routes, finding they converge on common checkpoints and that defensin effects are determined at the cell surface.

This paper shows human alpha-defensin 5 inhibits enterovirus A71 by stabilizing its capsid and blocking genome release during infection.

This paper identifies lineage-specific chromatin accessibility differences at IFN gene loci in pDCs and epithelial cells, revealing ETS-IRF composite elements as key regulators of divergent interferon responses.

This study identifies pathogenic yeasts in e-cigarettes that can cause lung disease in mice.

This study identifies how human alpha-defensins neutralize AAV2 and AAV6 by blocking viral entry and nuclear trafficking, revealing a common mechanism for inhibiting non-enveloped viruses.

This study investigates how post-translational modifications on adenovirus protein VII affect its function during early and late infection stages, revealing their role in localization, transcription, and protein interactions.

This paper shows that human adenoviruses can bind to cells via alpha-defensins instead of their usual receptors, expanding their tropism to non-susceptible cells.