Lingyun Xiong

This study identifies sex differences in tubuloglomerular feedback dynamics in rodent kidneys, showing males have higher oscillation frequencies but are more prone to TGF loss, leading to increased injury risk.

The paper identifies androgen receptor-mediated regulation of sexually dimorphic gene expression in the mouse kidney and finds limited conservation in human kidney.

This study introduces popInfer, a method for inferring gene regulatory networks from single-cell multiomics data, and applies it to uncover dynamic regulation of hematopoietic stem cell quiescence in mice under different dietary and aging conditions.

The paper shows that oncogenic alterations in the p53 pathway eliminate p53 oscillations, impairing its tumor suppressor function across various cancers.

The paper identifies heritable genetic variants in cancer genes that associate with both cancer risk and anthropometric traits in a large cohort.

The paper constructs a transcriptomic network model from time-series single-cell data to identify feedback loops driving cell fate transitions in mouse embryos.