GeneticsbioRxivPreprint
CRISPRa screen on a genetic risk locus shared by multiple autoimmune diseases identifies a dysfunctional enhancer that affects IRF8 expression through cooperative lncRNA and DNA methylation machinery
Tian Zhou, Xinyi Zhu, Zhizhong Ye…·Nan Shen
The paper identifies a dysfunctional enhancer linked to IRF8 expression through CRISPRa screening and shows its regulation by a lncRNA and DNA methylation.
DOI 10.1101/2021.06.11.448156