Lesilee S. Rose

This study identifies CED-10 as a component of the MES-1/SRC-1 pathway that regulates asymmetric division of the C. elegans EMS blastomere through actin regulation.

The paper investigates how PAR polarity is reestablished in the P1 cell of the two-cell C. elegans embryo, identifying two distinct pathways involving PAR-1, PKC-3, and myosin flow.

This study shows that PIG-1 and PAR-1 kinases redundantly regulate asymmetric division in C. elegans embryos by maintaining polarity and controlling spindle orientation.