ANNETTE C. DOLPHIN

The paper examines how alternative splicing of exons 18a and 47 affects the function and membrane targeting of human CaV2.2 channels, revealing combinatorial effects on conductance and surface expression.

The paper shows that T-type Ca2+ currents and persistent Na+ currents in ventral mEC stellate neurons increase excitability, distinguishing them from dorsal neurons.

This study shows capsaicin reduces presynaptic CaV2.2 expression in DRG neurons via Rab11a-dependent endocytosis, impairing neurotransmission.

This study investigates the role of CaV2.2 channels and α2δ-1 subunits in hippocampal homeostatic synaptic plasticity, showing their involvement in presynaptic Ca2+ dynamics and plasticity adaptation.

The paper shows that 2{delta}-1, but not 2{delta}-3, enhances CaV2.2 membrane expression via Rab11a-dependent recycling, affecting channel localization and function.

This study identifies ADAM17 as a protease essential for proteolytic maturation of 2{delta} subunits, which enhances calcium currents and is relevant to neuropathic pain.

The paper identifies 267 NaV1.7-associated proteins in mice using epitope-tagged gene targeting and mass spectrometry, including novel interactors validated by co-immunoprecipitation and functional assays.