Author

Mala M. Shah

UCL School of PharmacyORCID 0000-0002-8323-4739Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Assay:proteomics· 1

Frequent Co-Authors

Aleksandra Topczewska· 1 shared Andrés F. Correa-SáncheziD· 1 shared ANNETTE C. DOLPHINiD· 1 shared Aparna SinhaiD· 1 shared Elisabetta GiacaloneiD· 1 shared Elizabeth FisheriD· 1 shared Eugeni M. RyadnoviD· 1 shared Giampietro SchiavoiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Aleksandra Topczewska

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2 papers

Recent·Most cited

Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs

Matthew J. Keuss, Peter Harley, Eugeni M. Ryadnov, Rachel E. Jackson, Matteo Zanovello, Oscar G. Wilkins, Simone Barattucci, Puja R. Mehta, Marcio Guiomar Oliveira, Joanna E. Parkes, Aparna Sinha, Andrés F. Correa-Sánchez, Peter L. Oliver, Elizabeth Fisher, Giampietro Schiavo, , Pietro Fratta

This study shows that loss of TDP-43 causes synaptic dysfunction through a cryptic exon in UNC13A, which is rescued by antisense oligonucleotides.

bioRxiv · Jun 20, 2024 · PreprintNeuroscience

T-type Ca2+ and persistent Na+ currents synergistically elevate ventral, not dorsal, entorhinal cortical stellate cell excitability

Aleksandra Topczewska, Elisabetta Giacalone, Wendy S. Pratt, Michele Migliore, ANNETTE C. DOLPHIN, Mala M. Shah

The paper shows that T-type Ca2+ currents and persistent Na+ currents in ventral mEC stellate neurons increase excitability, distinguishing them from dorsal neurons.

Cell Reports · Jun 26, 2023Peer-reviewedNeuroscience