Makoto A. Lalwani

This study improves optogenetic control of protein production in K. phaffii by balancing EL222 and light doses, enhancing tunability and flexibility compared to methanol-based induction.

The paper introduces OptoAMP circuits that amplify light-induced transcriptional responses in microbial metabolism, improving control over metabolic pathways in fermentations.

This paper develops OptoLAC circuits to control gene expression in E. coli using blue light, improving metabolic engineering and protein production compared to IPTG induction.