Ralph L. Sacco

This study identifies 67 genetic loci associated with head size, finding strong overlaps with cancer pathways and genes, suggesting shared genetic mechanisms between head growth and cancer risk.

This study identifies three novel genetic loci associated with brain arterial diameters through a genome-wide association analysis across diverse populations.

This paper develops a radiomic signature from T2-FLAIR MRI images to predict white matter hyperintensities burden and links it to clinical phenotypes.

This study identifies sex-specific lesion patterns in acute ischemic stroke that correlate with stroke severity, highlighting differences in lesion distribution between men and women.

This study identifies genetic loci specific to periventricular and deep white matter hyperintensities, revealing distinct genetic architectures and potential biological mechanisms.

The paper presents an automated pipeline for quantifying white matter hyperintensity in acute ischemic stroke cohorts, showing improved accuracy and enabling large-scale analysis.

This study identifies 93 genetic loci associated with kidney function across four ancestry groups and highlights causal effects on kidney-related diseases.