Karen A. Mather

The paper evaluates a polygenic score for handgrip strength and its interaction with physical activity across twin cohorts, finding a significant genetic association and effect modification by physical activity.

The paper identifies seven age-associated circRNAs in the dorsolateral prefrontal cortex across the adult lifespan, linked to synapse regulation and post-transcriptional networks.

This study identifies genetic resilience factors for Alzheimer's disease by constructing polygenic resilience scores that reduce genetic risk penetrance and correlate with polygenic risk scores in unaffected individuals.

This study examines brain structural covariances in the ageing brain using UK Biobank data, finding age-related changes in cortical thickness and subcortical volume correlations, with sex differences and associations with cognition and longevity.

The paper examines age and sex effects on brain network topology in older adults and links these to cognitive performance using UK Biobank data.

This study identifies genetic variants associated with brain functional network measures in UK Biobank participants, linking them to sleep and psychiatric traits.

This study investigates the causes of variation in DNA methylation age across the lifespan, finding that environmental factors, particularly shared ones, are the main drivers.

This study examines the heritability and environmental influences on the plasma lipidome in older Australian twins, finding most variation is due to unique environmental factors.

This paper reports six novel genetic variants associated with Alzheimer's disease risk and demonstrates the utility of polygenic risk scores for risk stratification and age at onset prediction.

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.

This study identifies genetic loci specific to periventricular and deep white matter hyperintensities, revealing distinct genetic architectures and potential biological mechanisms.

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

This study investigates the association between CpG methylation and educational attainment, finding limited significant associations that may be influenced by confounding factors.