Author

Sophia B Scobell

National Institutes of HealthORCID 0000-0003-4630-0167Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

Meru J. SadhuiD· 3 shared Michael James ChambersiD· 3 shared Tristan R GrieveiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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3 shared papersGenetics

Meru J. SadhuORCID

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3 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintOct 1, 2026

Systematic screen of PKR reveals genetic variants that broadly evade divergent viral pseudosubstrate inhibitors

Michael James Chambers, Tristan R Grieve, Sophia B Scobell, Meru J. Sadhu

This study screens genetic variants of PKR to identify those that resist diverse viral pseudosubstrate inhibitors, finding shared resistance mechanisms across different inhibitors.

DOI 10.64898/2026.08.11.744216

humanprotein sequence

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GeneticseLifePeer-reviewedNov 12, 2024

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic

Michael James Chambers, Sophia B Scobell, Meru J. Sadhu

This study identifies K3-resistant variants in the PKR kinase domain and shows their enrichment under positive selection and resilience to viral adaptation.

1 citation

humanprotein structure

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GeneticsbioRxivPreprintNov 21, 2023

Systematic characterization of the local evolutionary space available to human PKR and vaccinia virus K3

Michael James Chambers, Sophia B Scobell, Meru J. Sadhu

The paper systematically explores genetic variants in human PKR and vaccinia virus K3 to understand their evolutionary dynamics and functional interactions.

DOI 10.1101/2023.11.21.568178

humanexperimental assay

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