Shilu Zhang

The paper develops L-HiC-Reg to predict long-range regulatory interactions in new cell lines and applies it to interpret GWAS SNPs in complex diseases.

This paper introduces scMTNI, a framework to infer cell type-specific gene regulatory networks on cell lineages using scRNA-seq and scATAC-seq data, showing its effectiveness on simulated and real datasets.

HiC-Reg predicts high-resolution Hi-C interaction matrices from regulatory signals, identifying topologically associated domains and CTCF motifs.