PSEN1-M146V and PSEN1-A246E mutations associated with Alzheimers disease impair proper microglia differentiation
Antoine Aubert, Maria Grazia Mendoza-Ferri, Aude Bramoulle…·Marco Antonio Mendoza-Parra
This study shows that PSEN1 mutations impair microglia differentiation, leading to pro-apoptotic and pro-inflammatory effects in brain organoids.