Author

Aude Bramoulle

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Marco Antonio Mendoza-ParraiD· 4 shared Antoine Aubert· 3 shared Bruno Maria Colombo· 3 shared François StüderiD· 3 shared Maria Grazia Mendoza-Ferri· 2 shared Alice MoussyiD· 1 shared Anne-Claire Comby· 1 shared Aysis KoshyiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersSystems Biology

Marco Antonio Mendoza-ParraORCID

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4 papers

Recent·Most cited

Krüppel-like factors KLF5 & KLF8 emerge as potential master transcriptional regulators of Alzheimer's disease, as revealed on cell fate regulomes in human brain organoids

Antoine Aubert, Anne-Claire Comby, Aude Bramoulle, Maria Grazia Mendoza-Ferri, Peggy Azzolin, Hongdou Li, Alice Moussy, Sudeshna Das, Bruno Maria Colombo, Marco Antonio Mendoza-Parra

The paper identifies KLF5 and KLF8 as master transcriptional regulators in Alzheimer's disease using human brain organoids and gene regulatory network analysis.

bioRxiv · Jul 24, 2026 · PreprintSystems Biology

PSEN1-M146V and PSEN1-A246E mutations associated with Alzheimers disease impair proper microglia differentiation

Antoine Aubert, Maria Grazia Mendoza-Ferri, Aude Bramoulle, François Stüder, Bruno Maria Colombo, Marco Antonio Mendoza-Parra

This study shows that PSEN1 mutations impair microglia differentiation, leading to pro-apoptotic and pro-inflammatory effects in brain organoids.

bioRxiv · Oct 8, 2023 · PreprintNeuroscience

A 3-dimensional molecular cartography of human cerebral organoids revealed by double-barcoded spatial transcriptomics

Gwendoline Lozachmeur, Aude Bramoulle, Antoine Aubert, François Stüder, Julien Moehlin, Lucie Madrange, Frank Yates, Jean‐Philippe Deslys, Marco Antonio Mendoza-Parra

This study develops a low-cost method for spatial transcriptomics and applies it to create a 3D molecular map of human brain organoids, showing gene expression differences across sections.

bioRxiv · Jan 18, 2023 · PreprintSystems Biology

Synergistic activation of RARb and RARg nuclear receptors restores cell specialization during stem cell differentiation by hijacking RARa-controlled programs

Aysis Koshy, Elodie Mathieux, François Stüder, Aude Bramoulle, Michèle Lieb, Bruno Maria Colombo, Hinrich Gronemeyer, Marco Antonio Mendoza-Parra

This study shows that activating RARβ and RARγ receptors with specific ligands enhances cell specialization during stem cell differentiation into neuronal and glial cell types.

Life Science Alliance · Nov 29, 2022Peer-reviewedMolecular Biology