NeuroscienceJournal of Biological ChemistryPeer-reviewed
Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation
Geetika Aggarwal, Subhashis Banerjee, Spencer A. Jones…·Andrew D. Nguyen
This study shows that antisense oligonucleotides can increase progranulin protein levels by blocking miR-29b binding in GRN mRNA, offering a potential therapy for FTD.
19 citations